After adjusting for a priori covariates and insulin status, users with T2D had a 1.27% (13.9 mmol/mol) HbA1c reduction (F=364.50, P<.001; 8.16% [65.7 mmol/mol] to 6.89% [51.8 mmol/mol]). The gene discussed is INS; the disease is type 2 diabetes mellitus.