There were also duplications in two participants from the expanded schizophrenia-LIQ group that overlapped two genes (ARSA and EIF2B1) associated with leukodystrophy, a progressive disease that causes abnormal development of and/or destruction of the myelin sheath and can present in adulthood with symptoms similar to that of schizophrenia [50, 51]. This evidence concerns the gene EIF2B1 and schizophrenia.