MAPT and Alzheimer disease: Several neurodegenerative diseases, such as Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Pick’s disease (PiD), argyrophilic grain disease, and inherited frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17T) are characterized by the presence of abnormal intracellular filamentous protein inclusions that consist of hyperphosphorylated microtubule-associated protein tau and are collectively designated as tauopathies [18, 26, 43].