Notably, JMJD6 regulated the alternative splicing of genes that are related to several KEGG signaling pathways, including MAPK signaling pathway, endocytosis, amino sugar metabolism, proteoglycans in cancer, 2-oxocarboxylic acid metabolism, and ubiquitin-mediated proteolysis (Fig. 2a). The gene discussed is JMJD6; the disease is cancer.