In light of our findings that JMJD6 is up-regulated in melanoma and the MAPK signaling is modulated by JMJD6 via regulation of the alternative splicing of PAK1 and the reported observation that a large proportion of melanoma carry BRAFV600E mutation rendering the MAPK signaling constitutive active [4], there appears existing a feedforward regulatory loop between JMJD6 and the MAPK signaling pathway in which genetic mutation of BRAF results in hyperactive MAPK signaling, which, in turn, leads to the activation of c-Jun. This evidence concerns the gene PAK1 and melanoma.