U2AF2 and melanoma: As JMJD6 has been reported to regulate RNA alternative splicing through hydroxylation of the alternative splicing regulator U2AF65 [14], to further explore the importance of JMJD6 in melanoma carcinogenesis and to understand the molecular mechanisms underlying the role of JMJD6 in the development and progression of melanoma, JMJD6 was knocked down in melanoma A375 cells using different JMJD6 siRNAs, and the influence of loss-of-function of JMJD6 on the global profile of the alternative splicing network was analyzed by RNA deep-sequencing (RNA-seq).