NME1 and Lymphatic Metastasis: Additionally, significantly lower positive rates of KAI1 and nm23 were found in LSCC with lymphatic metastasis than those without lymphatic metastasis (KAI1, 38.9 vs. 70.8%; nm23, 52.4 vs. 79.2%, respectively, all P < 0.05) (Table 2).