In this respect, and due to the pleiotropic nature of both TGFβ signaling as well as of Sirt1 activities, the possibility of Smad2 acting as a hub for Sirt1 action in the tight context of transcriptomic complexes, draws a special line of research that we intend to work through in the future, potentially opening opportunities for the development of innovative strategies to address diverse biological processes and pathologies including cancer. This evidence concerns the gene TGFB1 and cancer.