ESR1 and breast cancer: In the same line, the recent work of Sheng et al. showed that the estrogen receptor (ER) status in breast cancer cells influenced the gemcitabine efficacy: ER expression promoted cytotoxic autophagy through the enforced activation of the ER-ERK-p62/SQSTM1 pathway, whereas ER negative cells underwent cytoprotective autophagy [65].