Still, in this framework, Lamy et al. reported in multiple myeloma that caspase-10 inactivation (using Q-AEVD-OPH or shRNA targeting caspase-10) led to the stabilization of the BCLAF1/Bcl-2 complex and the unleashed activation of Beclin1, which is responsible for the autophagy process over-activation, culminating in autophagy-mediated cell death [76]. This evidence concerns the gene CASP10 and plasma cell myeloma.