IFNG and obesity due to melanocortin 4 receptor deficiency: Interestingly, in a model of concurrent HFD-induced obesity and colitis, dietary supplementation of n-3 PUFA reduced visceral AT gene expression of the Th1 subset signature cytokine, IFN-γ, and the Th17 transcription factor, RORγτ, and signature cytokine, IL-17, with no effect on FOXP3 expression [178].