Multiple studies have demonstrated the effect of LC n-3 PUFA supplementation in HFD-induced rodent models of obesity, including reduced visceral AT M1 macrophage accumulation in favour of M2 macrophage polarization [42,176,177,178,179,180,181,182], which is associated with decreased inflammatory mediator production and increased systemic insulin sensitivity [176,177,179] (shown in Figure 1). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.