Dietary LC n-3 PUFA have been shown to increase circulating levels of adiponectin in obesity in both humans [305,349,350,351,352] and rodent models [179,180,351,353,354], thereby attenuating the obesity-associated reduction in adiponectin [310,311,312,313]. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.