In this context, recently the Roden group has tested a naked-DNA vaccine expressing human calreticulin (hCRT) fused in frame to MmuPV1 E6 (mE6) and mE7 early proteins, and residues 11 to 200 of the late protein L2 (hCRTmE6/mE7/mL2) in the MmuPV1-infection model established in SKH1-e (hairless mice), in which a low percentage of animals are susceptible to MmuPV1 infections [211]. This evidence concerns the gene HCRT and infection.