COMMD1 and Zinc deficiency: As found during investigations in autistic patients, zinc deficiency during pregnancy caused epigenetic abnormalities in genes encoding MTF1, ZnT5, COMMD1 (COMM domain-containing protein 1), ERK1, TrkB (tyrosine-related kinase B), and ProSAP/Shank (proline-rich synapse-associated protein/SH3 and multiple ankyrin repeat domains) [252,253,254,255].