CACNA1C and Brugada syndrome: Additionally, malfunction in CaV1.2 channels is associated with cardiac disorders including Timothy syndrome that is characterized by a long QT interval and ventricular arrhythmia due to sustained activation of CaV1.2 channels, and Brugada syndrome that is notable for a short QT interval and sudden cardiac death due to inactivation of CaV1.2 channels [31].