KRTAP1-1 and cardiac hypertrophy: However, this study does not exclude the possibility that caveolae-resident LTCC could moderately affect the predisposition of the mouse heart to a lower-level stress, as β2a-trangenic mice displayed more severe cardiac hypertrophy under phenylephrine stimulation through Calcium/calmodulin-dependent protein kinase II (CaMKII)-mediated phosphorylation of caveolae-resident β2a subunits and the resulting up-regulation of caveolae-resident LTCC [36].