This is the case of the c-myc promoter that is strongly activated or repressed by PATZ1 in B lymphocytes and cervix carcinoma cells, respectively [2,3], or the case of three p53 target genes, CDKN1A, MDM2, and BAX, whose promoters are activated or repressed depending on the presence/absence of p53, which directly interacts with PATZ1, with consequent opposite functions on cellular apoptosis [1]. This evidence concerns the gene TP53 and cervical carcinoma.