Figure S1M shows that almost the entire protein can be engaged in the disorder-based interactions with protein partners. Finally, atrophin-1 is heavily decorated with a multitude of different PTMs. Human atrophin-1 is related to dentatorubral-pallidoluysian atrophy via pathological expansion of its polyQ tract [288] and was also shown to be at the center of the protein-protein interaction network related to the serrated colorectal carcinoma [289]. The gene discussed is ATN1; the disease is dentatorubral-pallidoluysian atrophy.