CD8A and infection: We then challenged mice with VSV-OVA or Lm-OVA to trigger the activation of mCTLs (Figures 2C–2F); Lm-OVA or IMQ/OVA immunized Tnfrsf11aΔItgax mice showed a significant impairment in mCTL activation upon infection with VSV-OVA, compared with littermate controls, as indicated by reduced expansion of OVA-specific CD8 T cells in the spleen (Figures 2C, 2D, and S2B).