As expected, GFP expression co-localized with CD169+ cells in the spleen MZ after infection with VSV-GFP, and there was a drastic reduction of GFP+ cells in spleens harvested from Tnfrsf11aΔItgax mice compared to littermate controls (Figures 4C and 4D); this correlated with a significant reduction in total VSV-GFP titers (Figure 4E). This evidence concerns the gene SIGLEC1 and infection.