The issue is a critical one given that mutations in the Chl1 human homologs ChlR1/DDX11 and BACH1/BRIP1/FANCJ collectively result in Warsaw Breakage Syndrome, Fanconi anemia, cell aneuploidy and breast and ovarian cancers [27], [31], [32], [34–40]. Here, DDX11 is linked to Warsaw breakage syndrome.