APP and endothelial dysfunction: Cherry et al., reported that high-LET iron radiation at doses of 10–100 cGy increased brain levels of soluble Aβ1–42 by 10–15% in male APP/PSEN1 TG mice (but not in females) at the age ~9 months, but amyloidosis was ascribed to endothelial dysfunction (reduced clearance of Aβ) rather than to enhanced neuroinflammation [51].