Although an increased Aβ deposition has not typically been observed in irradiated CNS, Cherry et al., found in APP/PSEN1 double TG mice predisposed to AD-related amyloidosis that a whole-body irradiation with 56Fe nuclei (1 GeV/n) caused elevation of brain Aβ levels, which they attributed to impaired Aβ clearance due to radiation-induced damage to the vasculature [51]. Here, APP is linked to Alzheimer disease.