A cluster of seven alleles associated with LTL homeostasis, TERC, TERT, oligonucleotide/oligosaccharide-binding fold containing one gene (OBFC1), zinc finger protein 208 (ZNF208), regulator of telomere elongation helicase 1 (RTEL1), acylphosphatase 2 (ACYP2) and nuclear assembly factor 1 ribonucleoprotein (NAF1) are simultaneously associated with CAD [185] and cancer [195,198]. The gene discussed is NAF1; the disease is cancer.