CNR1 and alcohol dependence: For example, single nucleotide polymorphisms in CNR1 (cannabinoid receptor 1) [22,23] and FAAH (fatty acid amide hydrolase) [24,25], the catabolic enzyme for n-acylethanolamides (NAEs), including anandamide (AEA), are associated with alcohol dependence and studies have found widespread cannabinoid receptor 1 (CB1) downregulation in the central nervous system (CNS) of human alcoholics [26], an effect that is recapitulated in rodent models.