VEGFA and disease arising from reactivation of latent virus: V-GPCR also promotes angiogenesis by activating multiple signaling pathways that are deregulated during latent infection, such as MAPK, PI3K/AKT, and NF-κB, leading to the upregulation of angiogenic factors, like vascular endothelial growth factor (VEGF), IL-6, and platelet-derived growth factor (PDGF) [94,95].