Such observed differences in the effect of IL-6-deficiency on hypertension is most likely reflective of differences in the model of hypertension employed, such as angiotensin II-induced versus stress-induced hypertension, as well as differences in methods used to measure blood pressure (tail-cuff plethysmography versus radiotelemetry) [57,184,185,186,187,188,189,190]. Here, AGT is linked to hypertensive disorder.