MUC1 and neoplasm: For example, GO-203—a 7-mer, cell-permeable, D-amino acid synthetic peptide derived from the MUC1-CT [119]—blocked MUC1-CT association with the p85 subunit of PI3K, induced reactive oxygen species-mediated death of NSCLC cells in vitro, and promoted regression of NSCLC tumor xenografts in nude mice in vivo [118].