On the other hand, loss-of-function mutations of SLCO2A1 is a causative gene for primary hypertrophic osteoarthropathy and chronic non-specific ulcers in small intestine, which are related to aberrant catabolism of PGE235,44,45; therefore, adverse effects of OATP2A1 blocking may be concerned as well. Here, SLCO2A1 is linked to primary hypertrophic osteoarthropathy.