Upregulation of genes encoding proinflammatory molecules such as IL1B, CCL26, CCL3, CCL8, CXCL1, CXCL11, CXCL12, CXL2 and CXCR7 in type 2 diabetic OD islets, but not in type 2 diabetic PPP islets, likely reflects a ‘wound’ response secondary to enzymatic isolation [53]. The gene discussed is CXCL1; the disease is osteochondritis dissecans.