SNCA and Autoimmunity: Recently, it was found that many PD patients contain activated T cells against the n-terminal of α-synuclein, suggesting PD may be a result of autoimmunity against this antigen.105 The entry of protein particles through leaky gut has been hypothesized as a factor leading to autoimmunity.106 Hence, it is an intriguing possibility that under conditions of a “leaky gut” dietary α-synuclein could enter host and result in an adaptive immune response.