Epigenetic regulation of gene structure/function may play a role in the PD.218–221 Specifically, dysregulation of PD genes may be controlled by epigenetic mechanisms.222,223 In contrast to somatic mutations and copy number variations,192,224–226 the epigenome is partially dynamic such that it is modifiable by environmental factors and with aging.227 Age-dependent epigenetic alterations have been shown accumulate more rapidly in PD patients.228 Furthermore, several PD-associated genes, including parkin (PARK2)226,229 and α-synuclein225,230,231 exhibit dysregulated activity in PD. The gene discussed is PRKN; the disease is Parkinson disease.