P2RX7 and neoplasm: Although the overstimulation of P2X7 receptor with agonists appears to be the most logical strategy to decrease tumor proliferation, by inducing both tumor cell death and antitumor immune response, recent studies have been demonstrated that blocking P2X7 receptor activation is more efficacious in preventing tumor growth, mainly in those cancers in which P2X7 receptor is overexpressed (28, 46, 47, 100).