NT5E and cancer: Elevated CD73 expression has been reported in several types of human cancers such as glioma (229–231), head and neck (128), melanoma (232), thyroid (233), breast (234–238), pancreas (239), colon (219, 240), bladder (241, 242), ovarian (243), prostate (244), and leukemia (126), being positively correlated with poor prognosis.