eATP acting exclusively through P2X7 receptor also inhibited colon carcinoma and melanoma tumor growth in C57BL/6 wild-type mice, by perturbing the balance between two signaling axes—P2X7-PI3K/AKT and P2X7-AMPK-PRAS40-mTOR—and promoting tumor cell death through autophagy (48). This evidence concerns the gene P2RX7 and colon carcinoma.