An important point to be considered is that the use of P2X7 receptor antagonists have been shown to demonstrate strong anticancer effects in immune-competent mice expressing P2X7 in both tumor and host side (47, 100), suggesting that blocking P2X7 on the tumor side is critical to the final antitumor action, despite the mild immunosuppressive effect due to inhibition of the P2X7 on the host side (53). The gene discussed is P2RX7; the disease is neoplasm.