P2X7 receptor activation also triggers NFATc1, Erk, PI3K/Akt, and HIF-1α intracellular pathways (101–103), being the PI3K/Akt pathway linked to the P2X7-dependent tumor cell growth, invasiveness, metastatic spreading, and angiogenesis (101, 104). The gene discussed is P2RX7; the disease is neoplasm.