A follow-up analysis by the same group reported a protective effect of combined KIR3DS1 and HLA-Bw4I80 against development of certain opportunistic infections in HIV-1–infected patients, also after controlling for presence of protective (e.g., HLA-B*57 and HLA-B*27) and deleterious (HLA-B*35) alleles (85). Here, HLA-B is linked to Opportunistic infection.