This two-stage case-control study, involving 2803 CAD patients and 2840 controls, aimed to investigate the associations of PARP-1 rs1136410 with CAD development, lipid levels, PARP activities, 8-hydroxy-2′-dexyguanosine (8-OHdG), and interleukin (IL)-6 levels in a Chinese Han population. Here, PARP1 is linked to coronary artery disorder.