5XFAD mice, which have previously shown various AD-like phenotypes, such as Aβ deposition, phosphorylated tau deposition, neuronal loss, axonal degeneration, and memory deficits (Oakley et al., 2006; Urano and Tohda, 2010; Joyashiki et al., 2011; Tohda et al., 2011, 2012) were used to model AD in the current study. The gene discussed is MAPT; the disease is Alzheimer disease.