As for postlingual-onset ANSD, a lot of syndromic forms that cause sensory and motor neuropathy have been documented in adults with ANSD, including Charcot-Marie-Tooth disease2,16,17, Friedreich’s ataxia18,19, deafness-dystonia-optic neuropathy (DDON) syndrome20, autosomal dominant optic atrophy (ADOA)21,22, and AUNX1 due to mutations in apoptosis-inducing factor23,24. Here, AIFM1 is linked to autosomal dominant optic atrophy.