PPI analysis of the SLE pathway revealed 9 functional interaction modules of histone variants (HIST1H2BO, HIST1H4A, HIST1H2BD, HIST1H2BL, HIST1H2BJ, HIST1H2BH, HIST1H4E, HIST1H4K and HIST3H2BB) that are associated with the prognosis of cervical cancer patients (Fig. 8). The gene discussed is H2BC13; the disease is cervical cancer.