PPI analysis of the SLE pathway revealed 9 functional interaction modules of histone variants (HIST1H2BO, HIST1H4A, HIST1H2BD, HIST1H2BL, HIST1H2BJ, HIST1H2BH, HIST1H4E, HIST1H4K and HIST3H2BB) that are associated with the prognosis of cervical cancer patients (Fig. 8). This evidence concerns the gene H2BC5 and cervical cancer.