The results demonstrated that the overall survival of patients with numerous DEGs (HIST1H3J, HIST1H2BD, HIST1H4K, HIST1H2AD, HIST1H2BH, HIST1H2BO, HIST1H2BL, HIST1H2BJ, HIST1H4E, HIST1H3C, HIST1H3D, HIST1H2AJ, HIST1H2AM, HIST3H2BB, HIST1H3F and HIST1H2AL) in the SLE pathway was significantly improved compared to those with fewer DEGs in the SLE pathway (p = 0.02104). The gene discussed is H3C3; the disease is systemic lupus erythematosus.