It has been shown in a variety of animal models of induced pathology by misfolded α-Synuclein that regardless of the nature of the injected material (i.e. pre-formed α-Synuclein fibrils, extracts from human brains with Dementia with Lewy Bodies (DLB) or Parkinson’s disease and brain lysates from symptomatic α-Synuclein overexpressing mice) and irrespective of the initial site of injection, a robust α-Synuclein pathology could be detected away from the injection site14,15,20–22. The gene discussed is SNCA; the disease is Parkinson disease.