MC4R and obesity due to melanocortin 4 receptor deficiency: Of the 48 loci that contained at least one prioritized gene from positional and eQTL mappings, chromatin interaction mapping identified candidate genes in additional 18 loci (Supplementary Fig. 2), including loci mapped to known genes associated with BMI such as MC4R, FOXO3, and ADCY9. The 400 prioritized genes showed enrichment in 9 GO terms, such as “response to zinc ion” and “oligopeptide binding” overlapping with multiple metallothionein and glutathione S-Transferase genes whose association with obesity risk has been reported45,46 (Supplementary Data 6).