However, both angiomyolipoma cell lines 621–101 and CRL4004 used in this work have multiple common features such as mTORC1 hyperactivation, differentiation abnormalities, binding of Notch1 to the RHEB and HES1 promoters, and oscillation of RHEB and HES1 mRNAs and proteins. The gene discussed is RHEB; the disease is angiomyolipoma.