We used a genetic strategy for cell-specific depletion of Tsc1 in the mouse embryo NT because expression of ID1 and ID3 was suppressed in angiomyolipoma cells in N-medium (Fig. 4i), Id proteins as well as high level of Hes1 prevent neurogenesis in NT50, 51, and Id3 and Hes1 are regulated by Notch154. The gene discussed is HES1; the disease is angiomyolipoma.