TSC1 and angiomyolipoma: Given the role of Notch signaling oscillation in maintaining the multipotency of NSCs and progenitors19 in conjunction with the phenotype of angiomyolipoma cells (Fig. 1 and Supplementary Figs. 1–3), and roles of Rheb and Notch in TSC tumorigenesis17, 18, we theorized that cycling of Rheb and Notch signaling in NSC-like angiomyolipoma cells prevents their differentiation.