The neuronal differentiation of angiomyolipoma cells was associated with reduced SOX9 and ID1 and ID3 (Fig. 4i), consistent with the role of Notch in the activation of these genes48, a role for SOX9 in maintaining multipotent NSCs49, and Id proteins in preventing neurogenesis in neural tube (NT)50, 51. Here, SOX9 is linked to angiomyolipoma.