We used a genetic strategy for cell-specific depletion of Tsc1 in the mouse embryo NT because expression of ID1 and ID3 was suppressed in angiomyolipoma cells in N-medium (Fig. 4i), Id proteins as well as high level of Hes1 prevent neurogenesis in NT50, 51, and Id3 and Hes1 are regulated by Notch154. This evidence concerns the gene TSC1 and angiomyolipoma.