We found that SAR1A expression was significantly reduced in AD brains compared with age-matched controls (APC p value = 0.04; STG p value = 0.0005; PO p value = 0.0000279) and associated with plaque load (APC p value = 0.062; STG p value = 0.0005; PG p value = 0.00638; PO p value = 0.00000911). Here, SAR1A is linked to Alzheimer disease.