CTSD and open-angle glaucoma: However, a study in the literature reported that the neurodegenerative marker in the AH of POAG eyes is not adequate; thus, the present study measured biomarkers of neurodegeneration (BDNF, cathepsin D, sICAM-1, MPO, sNCAM, sVCAM-1, and PAI-1) in the AH from POAG patients.