However, in November 2011, the approved licence for panitumumab was extended to cover its use as a first-line agent in combination with 5-fluorouracil/folinic acid + oxaliplatin (FOLFOX) chemotherapy and as second line in combination with 5-fluorouracil/folinic acid + irinotecan (FOLFIRI) chemotherapy, again restricted to patients with confirmed wild-type KRAS tumour status [7, 15]. This evidence concerns the gene KRAS and neoplasm.