SHBG and hypogonadism: HIV patients also tend to have higher levels of SHBG on average which may mask true hypogonadism if free testosterone is not tested, which underpins the importance of guideline adherence (Atan, Tuncel, Yesil, & Balbay, 2013; Martin, Benassayag, Amiel, Canton, & Nunez, 1992).