Of 357 consecutive tPA-treated patients, 67 were treated beyond 4.5 hours after stroke onset, 23 did not have a non-contrast CT follow-up at 24 hours, 37 did not have PCT at admission, 14 had a posterior cerebral artery infarction, 6 had a anterior cerebral artery infarction, 23 had a vertebrobasilar territory infarction, and 31 patients underwent mechanical thrombectomy after tPA treatment. This evidence concerns the gene PLAT and stroke disorder.