IGHE and allergic disease: Tregs and their cytokines suppress effector T cells and control the allergic diseases by several means which lead to reduced production of Th2 cytokines (IL-4, IL-5, IL-13); suppression of T cell homing to tissues; very early basophil tolerance and early decrease of mast cell and basophil activity; decrease numbers and mediator secretions of tissue mast cells and eosinophils; and suppression of excessive IgE synthesis and induction of IgG4 and IgA by allergen-specific B cells [32].