Our previous work showed the ability of cisplatin or LA-12 to effectively enhance TRAIL-induced apoptosis in human PC3 prostate cancer cells, which was associated with modulations of some upstream events in the extrinsic apoptotic pathway such as re-localization of DR4/5 into lipid rafts or TRAIL internalization [25]. This evidence concerns the gene TNFSF10 and Familial prostate cancer.