RCC is a family of cancers including five major subtypes (clear cell, papillary type I and type II, chromophobe, collecting duct, and unclassified RCC) that originate from the renal tubular epithelium, but unlike other epithelial cancers originating from other districts such as the colon, breast, lung, stomach and bladder, p53 mutations in RCC are particularly rare, especially in the ccRCC subtype. This evidence concerns the gene TP53 and cancer.