TRIM28 functions as a transcriptional corepressor in orchestrating the primer binding site-mediated silencing of integrated Moloney murine leukemia virus (M-MLV) proviruses in mouse embryonic carcinoma and embryonic stem cells [76], while TRIM19 (PML) regulates the asymmetric division of hematopoietic stem cells via the PPAR-δ-FAQ pathway [77]. Here, PML is linked to embryonal carcinoma.