Moreover, TRIM8 downregulation was also found in other tumours as Glioblastoma Multiforme (GBM), clear cell Renal Cell Carcinoma (ccRCC), anaplastic thyroid cancer (ATC), colorectal cancer (CRC), Chronic lymphocytic leukemia (CLL), and osteosarcoma cell lines [19,20,21,22,23,24,25,26]. The gene discussed is TRIM8; the disease is B-cell chronic lymphocytic leukemia.