Various biological processes have been shown to account for the pathogenesis and progression of DCM, including, but not are limited to, oxidative stress, cardiomyocyte apoptosis, disordered calcium handling, endoplasmic reticulum stress, myocardial insulin resistance, endothelial dysfunction, mitochondrial dysfunction, and autophagy [10, 11]; amongst which, oxidative stress is believed to be a key mechanism through which DM induces DCM. Here, INS is linked to familial dilated cardiomyopathy.