Similarly, in a mouse model of type 2 diabetes (T2DM), SFN was able to activate Nrf2 antioxidant signaling, the effect of which restored the oxidative stress-induced inhibition of liver kinase B1/5′ AMP-activated protein kinase (LKB1/AMPK) signaling pathway and prevented T2DM-induced lipotoxicity and cardiomyopathy [57]. This evidence concerns the gene NFE2L2 and type 2 diabetes mellitus.