ESR1 and ovarian carcinoma: We further tested the potential enhancement of antitumor effects of wogonin in ovarian cancer cells where ER-α signaling was blocked by treatment of methylpiperidinopyrazole (MPP), and our results showed that MPP significantly enhanced the inhibitory effects of wogonin on invasiveness and clonogenic survival of A2780 cells (Figures 2(c)–2(e)).