They also found that IL-1β-sensitive AML samples have increased phosphorylation of p38-MAPK, and that the p38-MAPK inhibitors doramapimod (BIRB-796) or ralimetinib could inhibit the IL-1β-dependent growth of AML patient mononuclear cells or AML CD34+ cells. The gene discussed is IL1B; the disease is acute myeloid leukemia.