Another high-expression signal pathway involved in the activation of macrophages by Bap was AGE-RAGE signaling pathway, of which the role in the progression of AAA has been reported by Zhang et al. Blocking RAGE in a mouse aneurysm model significantly inhibited the formation of aneurysms and prevented MMP-9 expression in macrophages [40]. The gene discussed is RENBP; the disease is aneurysm.