AR and Familial prostate cancer: Furthermore, ChIP-seq analysis performed using RNA from the AR-positive LNCaP and VCaP prostate cancer cell lines indicates AR directly regulates expression of glucose transporter 1 (GLUT1), hexokinases I and II, phosphofructokinase, CAMKK2, mTOR, and other gene products that play key roles in lipid and glucose metabolism [117].