CD274 and cancer: As shown in Figure 1C, at a concentration of 2 μM, mFc evidently bound to all eight tested viral proteins and cancer-related antigens, including HIV-1 gp140, Zika virus (ZIKV) envelope protein domain II (EDII), domain III (EDIII), mesothelin, 5T4, PD-L1, OX40, TIM-3.