CD226 and neoplasm: NKG2D recognizes stress-induced self-molecules, such as MICA/B and the ULBP family, upregulated in most neoplastic cell types (30); natural cytotoxicity receptors (NKp30 and NKp46) can recognize self-molecules exposed in damaged cells (i.e., BAT3, MLL5) or induced by inflammatory stimuli (i.e., B7-H6) (31, 32); and DNAM-1 specifically recognizes CD155 (PVR) and CD112 (Nectin-2), overexpressed in a variety of tumor types (33).