Independently of anti-HER2 mAbs, NK cell-DC crosstalk, involving cell–cell contacts and IFNγ, has been shown to prime DC polarization for IL-12 secretion, enhancing cross-presentation of tumor antigens to cytotoxic CD8+ T cells and the polarization of tumor-specific Th1 CD4+ T cells in preclinical models (59, 125–129). This evidence concerns the gene CD4 and neoplasm.