Another study found that in mice exposed to mechanical ventilation/LPS injury, S100A8/A9 deficiency saved mice from lung inflammation, as seen by decreased alveolar-epithelial permeability, low neutrophil influx, and less cytokine/chemokine release in BAL of S100A9 KO mice compared to WT mice (21). Here, IGKV1D-22 is linked to inflammatory response.