In our recent study, along with other findings, we observed improvements and prolongation of lifespan in amyotrophic lateral sclerosis (ALS) mice after transplantation of the umbilical cord blood mononuclear cells (UCB-MCs) simultaneously transduced with three adenoviral vectors (Ad) encoding vascular endothelial growth factor (VEGF), glial derived neurotrophic factor (GDNF) and neural cell adhesion molecule (NCAM). This evidence concerns the gene CHL1 and amyotrophic lateral sclerosis.