In our recent study, along with other findings, we observed improvements and prolongation of lifespan in amyotrophic lateral sclerosis (ALS) mice after transplantation of the umbilical cord blood mononuclear cells (UCB-MCs) simultaneously transduced with three adenoviral vectors (Ad) encoding vascular endothelial growth factor (VEGF), glial derived neurotrophic factor (GDNF) and neural cell adhesion molecule (NCAM). The gene discussed is VEGFA; the disease is amyotrophic lateral sclerosis.